Endocrine Abstracts

Background/Aim: Impact of age on hypothalamic –pituitary –thyroid axis, interesting from theoretical and practical aspects, have been studied. Our aim was to find out: correlation between T3 (triiodothyronine) and T4 (thyroxine) hormone level and old age, so as of other, for thyroid function relevant parameters: TSH (thyroid stimulate hormone), TRH (thyreothropin releasing hormone) test, thyroid ultrasonography, thyroid gland scintigraphy with 131 J, ...

Adrenocortical carcinoma (ACC) is a rare (incidence 1–2 per 1 million population) and heterogeneous malignancy with incompletely understood pathogenesis, unknown etiology and poor prognosis. ACC tends to grow and metastasize rapidly if untreated. The majority of cases are incidental diagnoses of advanced stage disease that metastasizes precociously due to its tendency to invade vascular structures. Among adults presenting with hormonal syndromes due to tumor excess secret...

Purpose: The goal of the study was to determine: existence and degree of diabetic cardiovascular autonomic neuropathy (DCAN) depending on the type of diabetes; influence on systolic and diastolic function of myocardium and correlation with coronary disease and cardiovascular risk factors; possibility of early detection and diagnostic value of cardiovascular tests (CVT).Methods: The study involved 90 participants: 30 patients with type 1 diabetes (T1DM), ...

Background/Aim.: Importance of glucoreglation qality in diabetes complication prevention was proven in numerous clinical studies. Aim of this study is to determine impact of glucoregulation and duration of diabetes on the incidence of chronic complications of diabetes in Republic of Srpska (RS).Method: Study model included subjects with T1D and T2D who participated in the two-year project in the RS. It was a cross-sectional study with 10...

Background /aim: Osteoporosis is a generalized bone disease, characterized by impaired bone firmness, resulting in an increased predisposition for fractures. In order to detect the subjects at risk for fractures, one should actively search for them, primarily in a group of postmenopausal women, considering clinical risk factors. Apart from others, the relevant risk factors are lack of estrogen and low body mass index (BMI <19 kg/m2).: The aim of this study was t...

Orlistat selectively inhibits gastrointestinal lipase, thereby preventing fat dissolution and reducing fat absorption. Many studies have shown good effect of Orlistat on parameters of metabolic syndrome and diabetes mellitus type 2.The aim of this study was to examine the effect of Orlistat on:body mass reduction, serum lipid level, blood pressure level, fasting plasma glucose level (FPG) by obese patients with prediabetes.Study in...

Introduction: In order to detect the subjects at risk for osteoporotic fractures, one should actively search for them, primarily in a group of postmenopausal women, considering clinical risk factors. Body mass index (BMI) is a well-known, significant predictor of bone mineral density (BMD) of entire skeleton.Aim: The aim of this study was to examine relationship between BMI and BMD in a group of postmenopausal women.Methods: The st...

Introduction: Depression often occurs as comorbid and concomitant disorder in patients with type 2 diabetes (T2D) complicating the course and outcome of the disease, prolonging the treatment and accelerating complications of diabetes, especialy cardiovascular complications. Numerous researches show significant presence of cardiovascular disorders in depressed patients with T2D that show up several year after first depressive episode. Mortality caused by cardiovascular disorder...

Dietary therapy, programmed physical activity and cognitive-behavioral therapy are basic measures in the treatment of obesity. Cognitive-behavioral therapy applies methods which change eating habits of obese persons, aiming to remove barriers relating dietary therapy and programmed physical activity. The goal is to try efficiency of applying cognitive-behavioral therapy in the program for the reduction of body mass of obese persons, versus the application of dietary therapy an...

Introduction: Chronic kidney disease (CKD) is growing problem nowadays. Disorder of mineral metabolism occurs in initialCKD and includes the changes of bone metabolism. Fibroblast growth factor 23 (FGF23) plays an important role in phosphate metabolism. Bearing in mind this physiological role of FGF23, but also it’s role in pathophysiology of mineral and bone metabolism, there is a growing interest in conducting clinical studies in patients affected by CKD. Our aim was to...